中文名 | Btk inhibitor 1 |
英文名 | Btk inhibitor 1 |
英文别名 | Btk inhibitor 1 |
CAS | 1412418-47-3 |
化学式 | C22H22N6O |
分子量 | 386.4497 |
溶解度 | 10毫米DMSO |
存储条件 | -20℃ |
产品用途 | (Rac)-IBT6A 是 IBT6A 的消旋体。IBT6A 是 Ibrutinib 的一种杂质。IBT6A 可用于合成 IBT6A-Ibrutinib 二聚体和 IBT6A 加合物。Ibrutinib 是一种不可逆的选择性 Btk 抑制剂,IC50 为 0.5 nM。 |
参考资料 展开查看 | 1. Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES.2. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.3. Liu N, et al. Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study. Org Biomol Chem. 2015 May 14;13(18):5147-57. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.588 ml | 12.938 ml | 25.877 ml |
5 mM | 0.518 ml | 2.588 ml | 5.175 ml |
10 mM | 0.259 ml | 1.294 ml | 2.588 ml |
5 mM | 0.052 ml | 0.259 ml | 0.518 ml |